Hug drug, love drug Substance abuse An oral designer analogue of amphetamine, a ‘schedule I’ controlled substance which may be fatal due to heat exhaustion and dehydration, combination with methadone, LSD, opiates–eg, heroin or Fentanyl, or anesthetics–eg, Ketamine; it is a popular ‘recreational’ drug of abuse, especially in a dance-party–see Rave–setting; at moderate doses, it causes euphoria, sense of well-being, enhanced mental or emotional clarity; at higher doses, hallucinations, sensations of lightness, depression, paranoid thinking, violent behavior Toxicity Serotonin neurotoxicity, sweating, dilated pupils, blurred vision, tachycardia, arrhythmias, fever, spasticity, hypotension, bronchospasm, acidosis, anorexia, N&V, HTN, faintness, chills, insomnia, convulsions, loss of voluntary muscle control, anxiety, or paranoia. See Designer drugs, ‘Ice.’, Rave party. Cf Eve.